MSU freshman Baylee Voigt pushed the Mustangs' advantage to 5-0 with a double down the right-field line in the fifth inning before Erin Knox came plate ward on Krisha Hamm's pinch hit sacrifice fly to center field to cap a four-run fifth inning.
West Texas A&M sophomore starter Hannah Newcomb (6-1) allowed four earned runs on 10 hits in five innings to take her first loss of the season after coming in with an LSC-best 0.95 ERA.
The Lady Buffs added single runs in the sixth and seven innings to close the final margin to four runs.
Midwestern State senior Kim Jerrick went 3-for-4 to pace the Mustangs' 11-hit attack, while Katy Vandewater and Knox added two hits each.
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